Research from University of Copenhagen in Public Health Provides New Insights.

According to a study from Copenhagen, Denmark, "The aim of this study was to investigate experts' opinions regarding the extent to which the introduction of pretesting for polymorphism of serotonin transporter promoter region (5-HTTLPR) as a routine intervention in clinical practice would lead to better clinical outcomes for depression patients. Using an internet survey system, authors of clinical studies addressing the topic of association of 5-HTTLPR genotyping with antidepressant response were contacted to participate in a Delphi study."

"Responses from 12 experts were used for the final analysis. According to the participants, the introduction of 5-HTTLPR genotyping will lead to 33.8, 48.2, 57.8, and 65.1% of patients reaching remission at 1, 2, 3, and 6 months, respectively. According to experts, application of 5-HTTLPR pretreatment genotyping might influence remission; however, the estimated remission rates with genotyping at first sight do not appear to be superior to existing practice, i.e. without genotyping. It is anticipated that a combination of 5-HTTLPR testing with other genomic variables, which have yet to be determined, and compliance measurements can improve clinical outcomes in the future," wrote S. Oestergaard and colleagues, University of Copenhagen (see also Public Health).

The researchers concluded: "At present, the introduction of 5-HTTLPR genotyping is expected to be used only in special situations."

Oestergaard and colleagues published the results of their research in Public Health Genomics (Anticipated Outcomes from Introduction of 5-HTTLPR Genotyping for Depressed Patients: An Expert Delphi Analysis. Public Health Genomics, 2010;13(7-8):406-414).

For additional information, contact S. Oestergaard, University of Copenhagen, Sect Social Pharmacy, Dept. of Pharmacology & Pharmacotherapy, University of Pk 2, DK-2100 Copenhagen, Denmark.

The publisher of the journal Public Health Genomics can be contacted at: Karger, Allschwilerstrasse 10, CH-4009 Basel, Switzerland.

Keywords: City:Copenhagen, Country:Denmark, Public Health

This article was prepared by Science Letter editors from staff and other reports. Copyright 2011, Science Letter via NewsRx.com.